UFC Undisputed 2010 is a mixed martial arts video game featuring Ultimate Fighting Championship  properties and fighters developed by Yuke’s and published by THQ. It is scheduled for release on May 25, 2010, for the Xbox 360, PlayStation 3 and for the first time PlayStation Portable. It is the second game to be released under THQ’s 2007 agreement with the UFC and it is a sequel to the successful UFC 2009 Undisputed. A teaser trailer of the game was shown on December 12, 2009 at the 2009 Spike Video Game Awards, where UFC 2009 Undisputed was named the Best Individual Sports Game, showing a first look at The Ultimate Fighter: Heavyweights contestant Kimbo Slice.

On February 23rd, video game retailer GameStop announced that James McSweeney was one of four exclusive pre-order bonus unlockable fighters. On March 2nd, Marcus Jones was unveiled as the second fighter included in the pre-order. On March 9th, Brendan Schaub was announced as the third bonus fighter. On March 16th, Roy Nelson was announced as the fourth bonus fighter. The full roster is expected to be finalized and revealed between March 15 and April 10.